Loss of Ovarian Function Results in Increased Loss of Skeletal Muscle in Arthritic Rats
نویسندگان
چکیده
منابع مشابه
Loss of Ovarian Function Results in Increased Loss of Skeletal Muscle in Arthritic Rats.
OBJECTIVE We studied the effects of loss of ovarian function (ovariectomy) on muscle mass of gastrocnemius and the mRNA levels of IGF-1, atrogin-1, MuRF-1, and myostatin in an experimental model of rheumatoid arthritis in rats. METHODS We randomly allocated 24 female Wistar rats (9 weeks, 195.3 ± 17.4 grams) into four groups: control (CT-Sham; n = 6); rheumatoid arthritis (RA; n = 6); ovariec...
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We show here that elevated levels of gonadotropins (luteinizing hormone and follicle stimulating hormone), as found in menopause or after ovariectomy, promote growth of human ovarian carcinoma by induction of tumor angiogenesis. Human epithelial ovarian cancer tumors progressed faster in ovariectomized mice. This induced growth could be attributed to the elevated levels of gonadotropins associa...
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ژورنال
عنوان ژورنال: Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics
سال: 2016
ISSN: 0100-7203,1806-9339
DOI: 10.1055/s-0035-1571265